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N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide

MRT68921

CAS: 1190379-70-4

Molecular Formula: C25H34N6O

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N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide - Names and Identifiers

Name MRT68921
Synonyms MRT68921
MRT-68921
MRT 68921
MRT68921(HCI)
MRT68921(HCl)
MRT68921 (free base)
N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop
N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-
CAS 1190379-70-4

N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide - Physico-chemical Properties

Molecular FormulaC25H34N6O
Molar Mass434.58
Solubility 10 mM in DMSO
Storage Condition-20℃
In vitro studyMRT68921 disrupts Autophagosome Maturation by inhibiting ULK1-specific, thus blocking autophagy.

N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide - Preparation solution concentration reference

 1mg5mg10mg
1 mM2.301 ml11.505 ml23.011 ml
5 mM0.46 ml2.301 ml4.602 ml
10 mM0.23 ml1.151 ml2.301 ml
5 mM0.046 ml0.23 ml0.46 ml
Last Update：2024-01-02 23:10:35

N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide - Reference Information

biological activity MRT68921 is a potent dual autophagy kinase ULK1/2 inhibitor, its IC50 was 2.9 nM and 1.1 nM, respectively.
TargetValue
ULK2 (Cell-free assay) 1.1 nM
ULK1 (Cell-free assay) 2.9 nM
Last Update：2024-04-09 21:04:16
N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide
Supplier List
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: MRT68921 Visit Supplier Webpage Request for quotation
CAS: 1190379-70-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: MRT68921 Visit Supplier Webpage Request for quotation
CAS: 1190379-70-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide
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